Tim Humphrey D. Phil
Research Themes
Divisional Themes
- Cancer and Haematology
Group Members
- Dr. Anoushka Davé
- Rachel Deegan, DPhil Student
- Jenny Moss, DPhil Student
- Dr. Andrew Savory
- Helen Tinline-Purvis, DPhil Student
- Carol Walker, Lab Manager
Selected Bibliography
- Cullen Jason K, Hussey Sharon P, Walker Carol, Prudden John, Wee Boon-Yu, Dave Anoushka, Findlay James S, Savory Andrew P, and Humphrey Timothy C (2007) Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition. Mol Cell Biol, 27(21):7745-57.
- George Vinoj T, Brooks Gavin, and Humphrey Timothy C (2007) Regulation of cell cycle and stress responses to hydrostatic pressure in fission yeast. Mol Biol Cell, 18(10):4168-79.
| Timothy.Humphrey@rob.ox.ac.uk | |
| Tel | +44 (0)1865 617327 |
| Fax | +44 (0)1865 617318 |
Dr. Tim Humphrey
The objective of the laboratory is to understand the cellular responses to genotoxic and environmental stress, and their relation to chromosome stability and cancer. Loss of heterozygosity (LOH), in which the second allele of a gene is lost, can lead to tumorigenesis through functional inactivation of tumour suppressor genes. LOH has been detected in familial and sporadic cancers at high frequencies, and regions of LOH can often extend several megabases or even to whole chromosome arms. We are investigating the mechanisms by which DNA double-strand breaks (DSBs) can generate chromosomal rearrangements leading to extensive LOH, and how such chromosomal rearrangements are suppressed in normal cells.
We are using the genetically amenable fission yeast Schizosaccharomyces pombe as our primary model system in which DNA damage responses are evolutionarily conserved. Findings made in fission yeast are being analysed further in higher eukaryotic cells. Research techniques employed include genetics, molecular biology and biochemistry.
Biography
Appointments
2007 Senior Group Leader, Radiation Oncology and Biology, Oxford University
2003-2007 Senior Group Leader, MRC Radiation and Genome Stability Unit
1997-2003 Group Leader MRC Radiation and Genome Stability Unit
1997 Director of Graduate Studies
1993-1997 Post-Doctoral Research Fellow, Harvard University
1991-1993 Post-Doctoral Research Fellow, Oxford University
1985-1987 Research Assistant, Heidelberg University
Awards Training and Qualifications
- 2003 MRC Career Appointment
- 1996- 1997 Charles A. King Trust Post-Doctoral Fellowship Award
- 1994- 1995 Human Frontiers Science Programme Fellowship Award
- 1993- 1994 European Molecular Biology Long-Term Fellowship
- 1991 D. Phil. Molecular Biology, Oxford University
- 1985 B.Sc. Hons. Brewing and Microbiology, Heriot-Watt University
