Ruth J Muschel M.D. Ph.D.
- Cancer and Haematology
- John Beech, Support Scientist
- Saif Bham, DPhil Student
- YunHong Cao, Laboratory Manager
- Ana Maria Gil-Bernabe, Postdoctoral Researcher
- Alex Gordon-Weeks, DPhil Student and Clinical Research Fellow
- Sally Hill, Research Scientist
- Julian Hughes, Senior Project Officer
- Kamila Hussien, Scientific Research Assistant
- JaeHong Im, Postdoctoral Researcher
- David Jiang, Masters Student
- Pavitra Kanaan, Postdoctoral Researcher
- Cat Kelly, Postdoctoral Researcher
- Su Yin Lim (Esther), Postdoctoral Researcher
- Chad McKee, Postdoctoral Researcher
- Stavros Melemendis, DPhil Student
- Serena Lucotti, DPhil Student
- Serena Lunardi, Postdoctoral Researcher
- Abul Siddiky, Clinical Research Fellow
- Thomas Tapmeier, Postdoctoral Researcher
- James Wilson, Postdoctoral Researcher
- Arseniy Yushalin, DPhil Student
- Zhao Lei, Lim Su Y, Gordon-Weeks Alex N, Tapmeier Thomas T, Im Jae H, Cao Yunhong, Beech John, Allen Danny, Smart Sean, and Muschel Ruth J (2013) Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis. Hepatology, 57(2):829-39.
- Fokas Emmanouil, Im Jae H, Hill Sally, Yameen Sabira, Stratford Michael, Beech John, Hackl Wolfgang, Maira Sauveur-Michel, Bernhard Eric J, McKenna W G, and Muschel Ruth J (2012) Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. Cancer Res, 72(1):239-48.
- Liu Stanley K, Bham Saif AS, Fokas Emmanouil, Beech John, Im Jaehong, Cho Song, Harris Adrian L, and Muschel Ruth J (2011) Delta-like ligand 4-notch blockade and tumor radiation response. J Natl Cancer Inst, 103(23):1778-98.
- Xu D, McKee C M, Cao Y, Ding Y, Kessler B M, and Muschel R J (2010) Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1 Cancer Res, 70(17):6988-98.
- Carbonell W S, Ansorge Olaf, Sibson Nicola, and Muschel Ruth (2009) The vascular basement membrane as "soil" in brain metastasis. PLoS One, 4(6):e5857.
Despite surgery and/or radiation, many cancer patients, who appear to have localised disease, go on to develop distant metastases. My research group is interested in the mechanisms underlying the development of metastasis.
We have used fluorescent microscopy to define the process of metastasis in the lung, finding adhesion of the tumour cells to the pulmonary blood vessels followed by spreading on the vasculature surface. Surviving cells give rise to early colonies formed within the blood vessels.
Some outstanding questions which we would like to answer are:
- What mechanisms do tumour cells use to arrest and survive at different metastatic organs?
- How do tumor cells interact with the host vasculature during metastasis?
- What are the mechanisms of metastasis to different organs, particularly the liver?
- Why does irradiation of the lung or tumour affect metastasis?
Awards Training and Qualifications
- 1978 M.D. Ph.D., Albert Einstein College of Medicine, New York
- 1972 B.A., Cornell University, Ithaca, NY