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Katherine A Vallis MBBS, PhD, MRCP, FRCR, FRCP(C)

CR-UK Senior Group Leader
Experimental Radiation Therapeutics
Development of novel anti-cancer radiopharmaceuticals.

Research Themes

Divisional Themes

  • Cancer and Haematology

Group Members

  • Zhongli Cai
  • Bart Cornelissen
  • Nadia Falzone, Oxford Nuffield Medical Fellow
  • Mark Jackson, DPhil Student
  • Ketan Shah, CRF, DPhil Student
  • Carol Target
  • Samantha Terry

Selected Bibliography

Email
Tel +44 (0) 1865 2 25850
Fax +44 (0) 1865 2 25850
PA Anne-Marie Honeyman-Tafa
Katherine A Vallis

Dr Katherine A Vallis

The goal of the Experimental Radiation Therapeutics Group is the development of novel anti-cancer radiopharmaceuticals.  We have been involved in the development of 111In-DTPA-EGF, which combines the Auger electron emitting isotope, 111Indium, with human epidermal growth factor, which targets EGFR-positive cancers. 111In-DTPA-hEGF is rapidly internalized and translocates to the nucleus.   111Indium emits densely ionizing Auger electrons that have a range of nanometers to micrometers and which are highly damaging to DNA.  We are building on our experience with 111In-DTPA-hEGF by designing and conducting pre-clinical investigations of other peptide-, antibody- and DNA-based agents.

Our three main research activities are: (1) The investigation of the radiobiological effects of Auger electron emitting radiopharmaceuticals (2) The pre-clinical development of molecularly targeted radiopharmaceuticals and (3) Early phase clinical trials of novel radiotherapeutic agents alone and in combination with other anticancer treatments.

Biography

2006 - Senior Group Leader
Radiation Oncology & Biology
University of Oxford

2005 - Associate Professor in Radiation Oncology and Medical Biophysics
University of Toronto

1995-2006 - Staff Radiation Oncologist
Princess Margaret Hospital
Toronto

Awards Training and Qualifications

  • 1995 Ph.D., University of Edinburgh
  • 1981 MBBS, The Medical College of St. Bartholomew's Hospital, University of London