Selected Bibliography

• Khoronenkova S V, Dianova I I, Ternette N, Kessler B M, Parsons J L, and Dianov G L (2012) ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage. Mol Cell.

• Markkanen Enni, van Loon Barbara, Ferrari Elena, Parsons Jason L, Dianov Grigory L, and Hubscher Ulrich (2012) Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination. Proc Natl Acad Sci U S A, 109(2):437-42.

• Meisenberg Cornelia, Tait Phillip S, Dianova Irina I, Wright Katherine, Edelmann Mariola J, Ternette Nicola, Tasaki Takafumi, Kessler Benedikt M, Parsons Jason L, Kwon Yong T, and Dianov Grigory L (2012) Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nucleic Acids Res, 40(2):701-11.

• Khoronenkova Svetlana V, Dianova Irina I, Parsons Jason L, and Dianov Grigory L (2011) USP7/HAUSP stimulates repair of oxidative DNA lesions. Nucleic Acids Res, 39(7):2604-9.

• Parsons Jason L, Dianova Irina I, Khoronenkova Svetlana V, Edelmann Mariola J, Kessler Benedikt M, and Dianov Grigory L (2011) USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta. Mol Cell, 41(5):609-15.

Grigory Dianov

In mammalian cells, Base Excision Repair (BER) is the major DNA repair system involved in the removal of various DNA lesions induced by ionizing radiation, including abasic sites and modified DNA base and sugar residues.  Alterations in BER  can lead to genome instability and the progression of human diseases, such as cancer, and indeed, the importance of BER regulation is highlighted by the fact that over-expression of BER proteins has been observed in several human cancers.  However, very little is known about the molecular mechanisms supporting the regulation of the BER process and the impact of mis-regulation of BER on genome stability and development of human diseases.  Our long-term goal is to study the proteins and mechanisms involved in the coordination and regulation of BER, to unravel their role in the repair of radiation induced DNA damage and to examine the relationship to human diseases, such as cancer.

Education

• 1980, Ph.D. in Molecular Genetics,
  

Institute of Cytology & Genetics, Novosibirsk, Russia

•   1987, D. Sci. in Biochemistry,
  

Institute of Cytology & Genetics, Novosibirsk, Russia

Appointments

• 2007- Senior Group Leader, Head of Biochemistry,
  

Gray Institute for Radiation Oncology & Biology, University of Oxford

•  2000- Senior Group Leader

Radiation & Genome Stability Unit, Medical Research Council, Harwell, UK

• 1995- Senior Staff Fellow

National Institute on Aging, NIH, Baltimore, USA

• 1993- Visiting Associate Professor, Department of Pathology,
  

University of Texas, Southwestern Medical Center, Dallas, USA

• 1990- Senior Research Fellow

Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, UK

• 1986- Laboratory Head

Laboratory of Molecular Mechanisms of Mutagenesis

Institute of Cytology & Genetics, Novosibirsk, Russia