Eric O’Neill B.A. M.Phil. Ph.D.
Research Themes
Divisional Themes
- Cell and Molecular Biology
- Proteomics
Unit Themes
Group Members
- Garth Hamilton
- Robert Latusek
- Simon Scrace
- Karen Yee
- Oliver Sampson, Joint Supervision
Selected Bibliography
- Matallanas David, Romano David, Hamilton Garth, Kolch Walter, and O'Neill Eric (2008) A Hippo in the ointment: MST signalling beyond the fly. Cell Cycle, 7(7):879-84.
- Matallanas David, Romano David, Yee Karen, Meissl Katrin, Kucerova Lucia, Piazzolla Daniela, Baccarini Manuela, Vass J K, Kolch Walter, and O'neill Eric (2007) RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell, 27(6):962-75.
| eric.oneill@rob.ox.ac.uk | |
| Tel | +44 (0) 1865 617321 |
Dr Eric O’Neill
Rasf1a is a tumour suppressor gene that is epigenetically silenced in a wide variety of sporadic human malignancies. Expression of alternative isoforms fail to substitute for RASSF1A promoted cell cycle arrest and apoptosis. Molecular events that lead activation of RASSF1A signalling are not well understood; however downstream signalling involves the tumour suppressors LATS1 and MST2. Moreover the signalling pathway emanating from RASSF1A is involved in the efficacy of the p53 family of tumour suppressors. Our research aim is to validate the extent to which RASSF1A/MST2 signalling contributes to an overall DNA damage response, via p53, and if RASSF1A silencing hampers the effectiveness of DNA damaging therapeutics. Moreover, utilising proteomics to identify interacting proteins we are able to highlight important regulatory steps in the pathway that can be manipulated to potentially re-sensitise RASSF1A silenced tumours to therapies such as radiation.
Awards Training and Qualifications
- 2002 Marie Curie Fellow, Beatson Institute, Glasgow
- 2000 Ph.D., Umea University, Sweden
- 1999 Fil. Lic. Molecular Biology, Umea University, Sweden
- 1995 B.A. Hons. Microbiology, Trinity College Dublin, Ireland
