Selected Bibliography

• Nicolay NH, Berry DP, and Sharma RA (2009 in press) Liver metastases from colorectal cancer: role of radio-embolization with systemic therapy Nature Rev Clin Oncol.

• Parsons JL, Tait PS, Finch D, Dianova IL, Edelmann MJ, Khoronenkova SV, Kessler BM, Sharma RA, McKenna WG, and GL D (2009 in press) Ubiquitin ligase ARF-BP1/Mule modulates base excision repair EMBO J.

• Yang J, Parsons J, Nicolay NH, Caporali S, Harrington CF, Singh R, Finch D, D'Atri S, Farmer PB, Johnston PG, McKenna WG, Dianov G, and Sharma RA (2009 in press) Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy Oncogene.

• Helleday Thomas, Petermann Eva, Lundin Cecilia, Hodgson Ben, and Sharma Ricky A (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer, 8(3):193-204.

• Sharma Ricky A and Dianov Grigory L (2007) Targeting base excision repair to improve cancer therapies. Mol Aspects Med, 28(3-4):345-74.

Dr. Ricky Sharma

The aim of the DNA Adduct Repair Group is to characterise fundamental biological mechanisms involved in the repair of adducts formed by reactive oxygen species, radiotherapy and platinum chemotherapies.  The ultimate goal of this research programme is to translate biochemical knowledge of adduct formation and repair into clinical studies of cancer prevention and treatment. 

The group is currently focussed on the effects of platinum chemotherapies on DNA.  These laboratory studies are ongoing in parallel with Dr Sharma’s clinical studies of oxaliplatin as a radiosensitiser in the treatment of liver metastases from colorectal cancer.  In collaboration with Dr Grigory Dianov’s group, cellular pathways of excision repair are being characterised in preclinical models as potential targets for improving current cancer therapies.

The research programme is funded by the
NIHR Biomedical Research Centre Oxford, Cancer Research UK, the UK Medical
Research Council via the Daphne Jackson Trust, the Bobby Moore Fund of Cancer
Research UK, Sirtex Medical Ltd. and the Higher Education Funding Council for
England.

Current Appointments

2009 HEFCE Clinical Senior Lecturer, University of Oxford

2006 - 2009  Senior Fellow, University of Oxford

2007 - Honorary Consultant in Clinical Oncology, Oxford Radcliffe Hospitals

Previous Appointments

2004 – 2006    Senior Registrar, Royal Marsden Hospital, London

2001 – 2006    Honorary Lecturer, University of Leicester

1998 – 2001    Clinical Research Fellow and Honorary Registrar, MRC Toxicology Unit and University Hospitals of Leicester

Degrees and Qualifications

2005  Fellow, Royal College of Radiologists

2001  Doctor of Philosophy, University of Leicester

1998  Member, Royal College of Physicians

1996  Master of Arts, University of Cambridge

1994  Bachelor of Medicine and Chirurgia, University of Cambridge

1992  Bachelor of Arts, University of Cambridge