Title

Research

We support investigator-led research through a large number of laboratories. This research covers three main themes of DNA Damage and RepairTumour Microenvironment, and Translational Research.

Research Groups

Cancer Therapeutics and mRNA Dysregulation

Investigating post-transcriptional mechanisms that drive cancer behaviour and researching novel...

 
Cancer and Immunogenetics Laboratory

Our major interests are in the fundamental genetics and biology of colorectal cancer and their...

 
Oncological Image Analysis

We develop image analysis methods for quantitative analysis of medical images,...

 
Nucleic Acids Research Group

We design and synthesise chemically modified DNA for diagnostic and therapeutic applications....

 
Computational Biology and Integrative Genomics

We search for integrated genomic blueprints that enable us to predict how cancer will evolve and...

 
Radiopharmaceuticals and Molecular Imaging Group

We aim to develop new radioisotope-labelled compounds for the imaging of tumour biology.

 
Cell Cycle and Ubiquitin Mediated Proteolysis Group

Our group objective is to identify novel pathways governing cell proliferation, which are...

 
Biochemistry and Regulation of DNA Repair Group

The long-term goal of the Dianov Laboratory is to study the proteins and mechanisms involved in...

 
Pancreatic Cancer Research Groups

We are investigating the mechanisms of tumour progression and resistance to radiotherapy and...

 
Novel Clinical Imaging Research Group

Our group focuses on using imaging techniques in small-scale trials with the particular...

 
Tumour Hypoxia Group

We are investigating how tumours survive in conditions which include low oxygen (hypoxia). Our...

 
Growth Factor Group

The focus of the group is on tumour angiogenesis and the role of notch signalling, and hypoxia...

 
New Technical Radiotherapy/Advanced Radiation Oncology Group

Personalising gastro-intestinal cancers radiotherapy: the ultimate aim of the research of my...

 
Tumour Radiosensitivity Research Group

Our research focuses on finding new ways of making tumours more sensitive to radiotherapy...

 
Chromosome Integrity Group

The aim or our research is to understand how genome stability is maintained in response to DNA...

 
Adjuvant Colorectal Cancer Group

Delivering the right treatment to the right patient at the right time.

 
DNA Repair in Cancer Treatment Group

We are investigating DNA damage signalling and repair factors in bladder cancer to develop new...

 
Cancer Cell Cycle Group

Research in Nick La Thangue’s group focusses on the mechanisms that give rise to the abnormal...

 
IGF Group

We are studying the role of insulin-like growth factor (IGF) signalling in tumour biology,...

 
Clinical Research Programmes, CRUK/MRC Oxford Institute for Radiation Oncology

We aim to deliver a step change in the effectiveness of radiotherapy through the evaluation of...

 
DNA Damage and Repair Group

We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and...

 
Head of Department, Molecular Resistance to Treatments Group

Our research links basic science with clinical applications and focuses on understanding the...

 
Early Phase Clinical Trials & Melanoma Therapy

Mark Middleton’s research concentrates on development of new cancer drugs and on the treatment...

 
Mechanisms of Metastasis Group

We are interested in the mechanisms underlying the development of metastasis, the spread of...

 
DNA Repair and Replication Group

We are working towards elucidating how cells resolve replicative stress arising from endogenous...

 
Cell Signalling Group

Our research aims to understand the cell and molecular biology behind frequent tumour mutations...

 
DNA Damage Group

Our research involves looking in to the process of radiation induced cluster DNA damage.

 
Radiotherapy Physics Research Group

We apply functional and molecular imaging techniques to developing radiotherapy personalised to...

 
DNA Damage Response Group

We are interested in the role of the ubiquitin-proteasome system in DNA repair, ageing, cancer...

 
Lung Cancer Research Group

Our group aims to identify novel therapies that target subgroups of lung cancer patients...

 
Oxford Molecular Diagnostics Centre

The aim of our research is to identify molecular-based disease classifiers using clinical omics...

 
Anticancer Viruses and Cancer Vaccines Group

The aim of our research is to design and develop innovative cancer killing viruses and oncolytic...

 
Translational Biomarker Development Group

We are developing and validating novel diagnostic tests and new imaging techniques to select...

 
Experimental Neuroimaging Group

Our goals are to identify the role of the inflammatory and metabolic microenvironment in brain...

 
Genome Stability and Tumourigenesis Group

Our research is focused on gaining a greater understanding of how homologous recombination, the...

 
Experimental Radiation Therapeutics Group

Personalising radiotherapy using functional imaging: we apply functional and molecular imaging...

 
Radiation Therapy Medical Physics Group

Our research group specialises in bringing fundamental physical concepts to enhance everyday...

 
Advanced Technology Development Group

Our work focuses on the application of novel imaging modalities and on the development of...

 

Core Facilities

Graham Brown, Core Leader

The Bioanalysis Core provides support in flow cytometry and in measuring concentrations of small...

 
Anastasia Samsonova, Core Leader

The Bioinformatics Core provides a nucleus for expertise in computational biology with a broad...

 
Daniel Bulte, Hub Leader

The Clinical Imaging Core supports the development and implementation of advanced imaging...

 
Frank Van den Heuvel, Academic Lead

The Clinical Radiotherapy Core supports the implementation of clinical trials involving novel...

 
Sandie Wellman, Core Leader

The Early Phase Clinical Trials Unit aims to support the translation of research findings in to...

 
Kevin Myers, Core Leader

The goal of the Oxford Experimental Cancer Medicine (ECMC) GCP laboratories is to accelerate the...

 
Sean Smart, Core Leader

The Imaging Core provides routine technical support services and operates a programme of...

 
John Prentice, Workshop Manager

The Mechanical Workshop assists numerous scientific groups within the Department and the...

 
Graham Brown, Core Leader

The Microscopy Core aims to provide research groups with imaging technologies to investigate...

 
Sarah Pearson, Trial Management Director

The Oncology Clinical Trials Office (OCTO) provides clinical trial management support to...

 
Rebekka Hueting, Core Leader

The PET Radiochemistry and Radiopharmacy core supports radiochemistry-dependent research...

 
Frances Willenbrock, Lead Scientist

The Preclinical Validation Core has been established to meet the need for rapid translation of...

 
Mark Hill, Core Leader

The Radiation Biophysics Core facilitates radiation research within the department and...

 
About Us
We aim to enhance clinical and basic cancer research in Oxford with the ultimate goal of increasing cancer cure rates.
Research
In Oxford, we have a great wealth of broad-ranging expertise and a powerful network of cancer researchers.
Study With Us
Our graduate training programmes for both scientists and clinicians are internationally recognised.