We wish to recruit a full-time chemist to join the Experimental Neuroimaging Group, headed by Dr. Nicola Sibson, in the Gray Institute for Radiation Oncology and Biology, University of Oxford.

One of the primary goals of the research in Dr. Nicola Sibson’s laboratory is to develop novel targeted contrast agents, in close collaboration with Professor Ben Davis in the Department of Chemistry, for use with magnetic resonance imaging. These agents have demonstrated enormous potential for identifying neurological disease acutely when it is undetectable by conventional, clinically used, imaging techniques. This particular project will involve the production of antibody or sugar conjugated contrast agents that will feed into an established Phase 1 toxicology screening programme. This project is a key element in taking our contrast agents through the translational pipeline to clinical trials.

The appointed candidate will have a PhD in Chemistry, Chemical Biology or Biochemistry or equivalent scientific experience. A high level of technical competence in chemical synthesis techniques, especially those associated with bioconjugates, peptide and carbohydrate synthesis, and particles/nanoparticles is essential.  Experience with techniques at the chemistry-biology interface and/or in the development of MRI, PET or SPECT contrast agents would be highly beneficial.  This post may suit individuals from an industrial background with the relevant experience.

The holder of this post will be located primarily in Prof. Davis’ group within the Chemical Research Laboratory, Oxford, but will be jointly responsible to Dr Sibson and Prof. Davis and will participate fully in the group activities of both laboratories.