Opportunities

Research Assistant - Radiopharmacy and Molecular Imaging Group

Closing Date: Oct 31, 2014 12:00 PM

We have an excellent opportunity for a Researcher Assistant to join the Department of Oncology. You will join the Radiopharmacy and Molecular Imaging Group, led by Dr Bart Cornelissen. The aim of the group is the development of novel preclinical imaging agents for oncology. You will undertake and support research into the development of new peptide-based imaging agents for in vivo non-invasive SPECT and PET imaging. Your duties will also include design and execution of experiments and strategy using a broad range of techniques, including radiolabelling, microscopy, and in vivo molecular imaging. You will have at least a BSc or MSc in Chemistry, Biochemistry, Molecular Biology or a related science. You will have strong experimental skills, as well as demonstrated ability to design and carry out laboratory studies using a range of experimental techniques. You will also hold a home office personal license and have previous experience in a laboratory environment. This is a full-time post and is fixed-term for 1 year in the first instance. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Friday 31 October 2014.

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Postdoctoral Researcher - Oncology

Closing Date: Nov 03, 2014 12:00 PM

We have an exciting opportunity for a Postdoctoral Researcher to join the Department of Oncology. You will investigate the role of somatic mutations in lung cancer and their impact on tumour cell responses to standard and novel therapies and radiation. Your duties will also include generating high quality data and reports, presenting results in oral and written form and contributing to the preparation of manuscripts. You will be expected to demonstrate initiative, both in experimental design and interpretation of data, and in disseminating research findings. You will have a PhD/DPhil in Biology, Biochemistry, Molecular Biology or a related biological/medical science. You will have expertise in standard molecular biological, biochemical and tissue culture related techniques. Demonstrable ability to evaluate and interpret scientific data is also required. This is a full-time post and is fixed-term until 31 March 2017. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Monday 3 November 2014.

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Senior Clinical Researcher in Experimental Therapeutics

Closing Date: Nov 14, 2014 12:00 PM

The Department of Oncology which incorporates the Cancer Research-UK/MRC Gray Institute for Radiation Oncology and Biology, within the Medical Sciences Division, aims to develop truly multidisciplinary and collaborative oncology research in Oxford. Working closely with colleagues in the new state-of-the-art NHS Oxford Cancer Centre, research can be rapidly and efficiently translated into cutting-edge clinical treatment for cancer patients. The postholder is expected to lead a programme of research trials and clinical cancer activity for the Department of Oncology and the Oxford Cancer Research Centre. The postholder will develop clinical research questions and have the skills necessary to design and progress these questions into early phase trial activity, taking a leading role in the Early Phase Trials Unit. The post would suit a consultant Medical Oncologist with a focus in a disease area which aligns to and complements that of the Oxford Cancer Research Centre. The postholder will be expected to develop their own independent, innovative research programme, working in collaboration with both basic and translational groups in Oxford and will have a regular commitment to appropriate clinical activity which will support the trials programme. An honorary contract with the Oxford University Hospitals Trust will be required for the successful candidate. A professorial title may be sought from the University for suitably qualified candidates. All applicants must complete a short application form; upload a CV and supporting statement. Applications should contain names and addresses of three referees (one of which should be your current or most recent employer), details of GMC registration and CCT. The closing date for applications is 12.00 noon on Friday 14 November 2014. The selection process will take place on Friday 5 December 2014.

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Clinical Research Training Fellowships (two posts)

Closing Date: Nov 14, 2014 12:00 PM

We are now inviting applications for the 2015 Clinical Research Training Fellowship DPhil intake for the CRUK & MRC Oxford Institute for Radiation Oncology at the University of Oxford. The fellowships are available to medically qualified individuals who are undertaking their specialist training in any clinical discipline, and who want to obtain a DPhil with a view to an academic career in any branch of cancer research. Candidates must be clinically qualified, and able to be GMC registered. Priority will be given to those in training in Radiation/Clinical Oncology but candidates from any discipline involved in the diagnosis and treatment of cancer are welcome. Applicants should demonstrate some previous research experience, which may include peer-reviewed publications, and have a strong commitment to the future pursuit of research. We strongly advise prospective applicants to discuss their research interests with potential supervisors prior to applying. Further information on available projects can be found in the attached documents, or by contacting Mrs Claire Garbett, PA to Professor Tim Maughan, the Clinical Director of the CRUK & MRC Oxford Institute for Radiation Oncology; email claire.garbett@oncology.ox.ac.uk or telephone 01865 617415. The posts will be available for three years in the first instance, with a commencement date to be negotiated with the successful fellows. In addition to a salary for three years, the fellowship will fund full tuition and college fees for the duration of training. All applicants must complete a short application form and upload a CV, supporting statement and supplementary information form. Interviews are scheduled for the first two weeks of December 2014. The closing date for applications is 12.00 noon on 14 November 2014.

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Research Assistant Histopathology

Closing Date: Dec 03, 2014 12:00 PM

An exciting opportunity has arisen for a Research Assistant - Histopathology within the CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology. In this new role, you will provide experimental support and expertise to Principle Investigators and other scientists on obtaining, processing, and analysing tissue samples. You will establish, train and deliver standard methodologies. Your duties will also include designing, evaluating and introducing the use of new techniques and stains specific for individual projects. You will have proven experience in preclinical and/or clinical histopathology laboratory tissue handling and processing techniques including using fresh, frozen and paraffin embedded cells and/or tissue specimens. You will also have proven experience of histopathological and immunohistochemical staining (chromogenic and fluorescence) techniques, including data interpretation and analysis skills. This is a full-time post and is fixed-term until 31 March 2017. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on 3 December 2014.

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Clinical Research Training Fellowships - Cancer Research UK Oxford Centre (4 posts)

Closing Date: Dec 10, 2014 12:00 PM

These 3-year fellowships are aimed at clinical trainees, providing them with an opportunity to work in a high calibre research environment, while studying for a DPhil. The principal aim is to provide high quality research training in basic and applied science, tailored specifically to the needs of talented clinicians who aspire to a career in academic medicine. The fellowships are structured around existing research programmes. These provide first class research environments for clinician scientists and have a framework for research and training in the combined fields of basic science and clinical medicine. Each training fellowship will be tailored to form a partnership between basic scientists and clinician-scientists, with the aim to bridge the gap between basic and applied research. The fellowship may be held at a number of University departments, and this will be dependent on the choice of project. Candidates will be required to include the proposed research project details in their fellowship application, from a range available. Please review available research opportunities in your field of interest via the included project booklet. We advise prospective applicants to discuss their research interests with potential supervisors prior to applying. All applicants must complete a short application form and upload a CV, supporting statement and supplementary information form. We request that candidates do not attach research papers or publications to their application. These full-time posts are fixed-term for 3 years. The start date for successful candidates would ideally be October 2015. The closing date for applications is 12.00 noon on 10 December 2014. Interviews are scheduled to be held on 27 January 2015.

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Postdoctoral Researcher – Optimisation of Radiation Therapy

Closing Date: Dec 19, 2014 12:00 PM

An exciting opportunity has arisen for a Postdoctoral Researcher to lead a research project, the aim of which is to develop a platform for evaluation of external beam radiotherapy (EBRT) including proton beam therapy and targeted theranostic agent combinations. This will involve evaluation of the biodistribution and efficacy of the theranostic agents in in vitro and in vivo models. You will have a PhD in medical imaging, radiation sciences or a related field and will have excellent bench skills in relevant laboratory techniques. Experience with murine cancer models and in vivo imaging (microSPECT/CT and nanoPET/CT) is essential. Experience of successfully preparing and submitting scientific data for publication is also essential, together with a strong publication record at the level of first author publication in a leading journal. This is a full-time post and fixed-term until 31 March 2017 in the first instance. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on 19 December 2014.

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Research Assistant in Tumour Hypoxia

Closing Date: Jan 02, 2015 12:00 PM

An exciting opportunity has arisen for a Research Assistant to join Dr Ester Hammond’s group whose research is primarily based on the study of tumour hypoxia and how this impacts both tumour progression and therapy resistance. You will support ongoing projects within the laboratory focused on novel therapeutic strategies for the treatment of oesophageal cancer. Experimental work will involve the culture of cell lines, clonogenic assays, western blotting and other standard cell biology techniques. You will also be required to assist with the supervision of new scientists and students in the laboratory. You will be a highly motivated, enthusiastic individual with a BSc/MSc or equivalent in biochemistry, molecular biology or a related science, with an interest in cancer biology and the tumour microenvironment. Previous experience in a laboratory environment and the ability to design and perform robust, well controlled experiments are essential, as is experience of cell culture. All applicants must complete a short application form and upload a CV and supporting statement. Full-time or part-time hours will be considered. Funding is available for 18 months if full-time and longer if part-time. Please specify the hours you would prefer to work in your supporting statement. The closing date for applications is 12.00 noon on 2 January 2015.

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Core Scientist in Mass Spectrometry

Closing Date: Jan 05, 2015 12:00 PM

An exciting opportunity has arisen for a Core Scientist in Mass Spectrometry (MS) to join the Cancer Research UK/Medical Research Council Oxford Institute for Radiation Oncology. You will join our Bioanalysis Core Group which currently provides mass spectrometry services and is responsible for developing the provision of proteomics support to our scientists. Your focus will be coordinating and supporting experiments from research groups in the Department of Oncology that require mass spectrometry, utilising MS laboratory facilities in the department and those in the NDM Research Building. This will include active participation in planning experiments, sample collection, preparation and running, as well as servicing and troubleshooting the main instrumentation in the department and the NDM Research Building MS lab, and contributing to analysis of the data. We are searching for an enthusiastic scientist with a PhD/DPhil in cancer biology, biological sciences (biology, immunology, medicine, biochemistry) or analytical chemistry. You will also have experience in proteomics and oncology and the ability to deliver work of a high standard. Previous experience in tandem mass spectrometry, cancer biology, good communication skills and the ability to work as part of a team are essential. The research involves recombinant DNA, tissue culture and biochemistry techniques, with the main focus on proteomics related methods such as sample preparation for MS analysis and data analysis tools. You will have a shared responsibility in training and supervising less experienced staff and students of the University of Oxford. This is a full-time post and fixed-term until 31 March 2017. The closing date for applications is 12.00 noon on 5 January 2015.

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Postdoctoral Researcher - Epigenetics and Tumourigenesis

Closing Date: Jan 05, 2015 12:00 PM

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Department of Oncology. You will join Dr Eric O’Neill’s research team, which focuses how the emerging microenvironment influences tumour suppressor events in developing neoplasms (Pefani et al. NCB 2014). You will work on developing tools and methodologies to visualise epigenetic events, DNA replication, EMT, dedifferentiation and stemness in 3D and in vivo models with state of the art microscopic techniques. In this role you will identify and design experiments to address signal pathways influencing cell fate decisions in response to inflammation and/or cell stress. Your duties will also include generating high-quality reproducible data, analysing data using appropriate statistical tools, contribute to the preparation of manuscripts and co-ordinate experiments with technical staff, group members and other scientists. You will have a DPhil or equivalent in relevant subject, as well as knowledge 3D tissue culture or In vivo disease models. You will have effective scientific communication skills, both oral and written. You will be able to demonstrable the ability to evaluate and interpret scientific data. You will be capable of independent thought and initiative in design and execution of experiments, with the ability to work flexibly and supportively as part of a team. This is a full-time post and is fixed-term until 31 March 2017. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Monday 5 January 2015.

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Clinical Imaging Hub Leader – MRI Physics

Closing Date: Jan 30, 2015 12:00 PM

An exciting opportunity has become available within the Department of Oncology, working in close collaboration with the Churchill Hospital NHS Radiology Department. We are seeking a physicist with significant training and experience in clinical MRI to lead a small research imaging physics team. The postholder and their team will collaborate with Oncology Department groups to develop imaging components of clinical trials and will play a key role in the quality assurance and analysis of trial data. In addition the postholder will work closely with both University and NHS teams to develop and implement state of the art imaging medical image acquisition and processing techniques and support their use in University-sponsored clinical trials within the NHS. You will have a PhD in imaging, medical physics or a related subject, as well as significant clinical experience of MR imaging and experience of clinical trial support. You will also have experience of successfully preparing and submitting scientific data for publication. This is a full-time post and is fixed-term to 31 March 2017. All applicants must complete an application form and upload a supporting statement. The closing date for applications is 12.00 noon on 30 January 2015.

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