Opportunities

Postdoctoral Researcher

Closing Date: Feb 26, 2014 12:00 PM

We have an exciting opportunity for a Postdoctoral Researcher to join the Group headed by Dr Anne Kiltie. The primary goal of this Group is to investigate the role of DNA damage signalling and DNA repair as they relate to the aetiology of bladder cancer and its response to radiotherapy and combined modality treatments.

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Clinical Research Training Fellow

Closing Date: Mar 27, 2014 12:00 PM

The Department of Oncology has an exciting opportunity for a Clinical Research Training Fellow to work in Dr Maria Hawkins’ Advanced Radiation Oncology Group which aims to improve radiotherapy techniques maximising outcomes and minimising toxicities in solid malignancies (focusing on gastro-intestinal and thorax systems). The group works closely with research medical physics groups and is translated in clinic at Oxford University Hospitals. This funded 3-year position provides the opportunity for a senior clinical trainee to work towards a DPhil in a high calibre research environment. The principal aim is to provide high quality research training focusing on radiotherapy and its applications. The role is tailored specifically to the needs of talented clinicians who aspire to a career in academic medicine. The successful candidate will be a GMC registered Medical Practitioner, with relevant and substantial hospital service, including clinical experience in radiotherapy. You should have passed FRCR part 2 or international equivalent and be able to provide evidence of adequate clinical oncological experience. You should also be familiar with radiotherapy planning technology and interpretation of radiotherapy plans. This is a full-time post offered for 3 years. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on 27 March 2014.

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Postdoctoral Researcher

Closing Date: Apr 04, 2014 12:00 PM

An excellent opportunity has arisen for a Postdoctoral Researcher to join Dr Kristijan Ramadan’s laboratory at the Gray Institute for Radiation Oncology and Biology, Department of Oncology. You will be part of an enthusiastic research team investigating the role of p97/VCP and the ubiquitin proteasome system in Genome Stability, Ageing and Cancer. You will further investigate the molecular structures, interactions and biochemical properties of the components of the ubiquitin proteasome system in DNA repair using X-ray crystallography and standard biochemical methods. Under direct supervision of the principle investigator you will tightly collaborate with the leading X-ray crystallography groups at the University of Oxford. You will have a PhD/DPhil in Biochemistry, Molecular Biology, Biophysics or a related science. A high level of technical competence and substantial experience in standard molecular biological and biochemical techniques is required, as is a willingness to develop a deep understanding of relevant DNA repair mechanisms and protein structures. You will also have at least one peer-reviewed original first author article in a recognised international journal. This is a full-time post and is available until 31 March 2017 in the first instance. All applicants must complete an application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Friday 4 April 2014.

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Research Assistant

Closing Date: Apr 04, 2014 12:00 PM

An exciting opportunity has arisen for a Research Assistant to join Dr Anderson Ryan’s Lung Cancer Research Group within the Department of Oncology. With funding support from the Oxford Cancer Research Centre (OCRC) the group is increasing its capability for preclinical testing of novel concepts in cancer therapy in order to provide a strong scientific rationale for entering clinical studies. As part of the initiative, this post is being created to lead in vivo drug evaluation and testing. Working under the supervision of the Group Leader you will design, execute and interpret in vivo anti-tumour efficacy studies. You will use a range of techniques (e.g. immunohistochemistry, FACS) to identify and evaluate potential novel biomarkers and will have the opportunity to work with diverse preclinical model systems and with a wide range of therapeutic approaches and biological mechanisms. Experience in oral, i.p., i.v. and s.c. substance administration would be desirable. This is a full-time post and is available for 1 year in the first instance. All applicants must complete an application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Friday 4 April 2014.

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Senior Postdoctoral Researcher

Closing Date: Apr 10, 2014 12:00 PM

An opportunity has arisen for a Senior Postdoctoral Researcher to join the Gray Institute’s Experimental Therapeutics Group, the aim of which is to design, synthesise and test radiopharmaceuticals for imaging and treatment of cancer. You will lead scientific projects concerning the macro- and micro-dosimetry of radionuclide-based theranostic agents to progress the development of clinically applicable dosimetric systems. The work will span the conduct of pre-clinical experiments designed to define their distribution and dosimetry from the sub-cellular to whole organism scales. You will have a PhD in imaging or medical physics and have proven expertise in micro- and macro-dosimetry for radionuclide therapy. Demonstrated ability to conduct experiments using preclinical laboratory models of cancer is also essential. HPC registration and a publication record including first-author publications are desirable. This is a full-time post and is available until 31 March 2017. All applicants must complete an application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on 10 April 2014.

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Postdoctoral Researcher in Bioinformatics/Statistics

Closing Date: Apr 11, 2014 12:00 PM

An opportunity has arisen for a Postdoctoral Researcher to join the Department of Oncology working under the supervision of Dr Francesca Buffa. The work will involve the integration of bioinformatics and genome-wide data-mining approaches with cancer physiological models, to develop tools for clinical decision making. The postholder will be involved in development and implementation of data-mining methods, as well as analysis of samples from clinical studies and a wide range of experimental model systems. You will have a PhD or equivalent experience in a relevant area. Previous experience in data-mining, as well as programming experience with at least one of the following: R, PERL, Java, C++, MatLab is also essential. You will also have expertise in the manipulation of large multivariate genomic/genetic datasets in human disease, preferentially cancer. This is a full-time post and is available for 3 years in the first instance. All applicants must complete an application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Friday 11 April 2014.

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Senior Bioinformatician/Software Engineer

Closing Date: Apr 11, 2014 12:00 PM

An opportunity has arisen for a Senior Bioinformatician/Software Engineer to join the Department of Oncology, managing key projects and defining bioinformatics and analytical strategies in collaboration with the group leader, Dr Francesca Buffa. You will be expected to contribute actively to existing collaborations and research projects, and to take leadership when required. The postholder is envisaged to project manage analyses pipelines, develop and implement data-mining methods for the analysis of genomics data (next-generation sequencing and other technologies) from clinical studies and a wide range of experimental model systems. You will have a PhD or equivalent experience in a relevant area and significant postdoctoral or equivalent experience working in a bioinformatics role. Excellent programming experience with at least one of the following: R, MatLab, Phyton, C++, Java, PERL is also essential. An excellent track record in analysis of large human cancer genomic datasets would be desirable. This is a full-time post and is available for 3 years in the first instance. All applicants must complete an application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Friday 11 April 2014.

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Postdoctoral Researcher - Omologous Recombination Repair in Genome Integrity and Cancer

Closing Date: Apr 17, 2014 12:00 PM

Applications are invited for a postdoctoral research position within the Telomeres and Genome Stability Group led by Dr Madalena Tarsounas at the Gray Institute in Oxford. We are looking for a strongly motivated postdoctoral candidate interested in joining our international team. The primary goal of the Group is to investigate how factors involved in DNA repair by homologous recombination contribute to telomere maintenance and genome integrity. The successful candidate will aim to define at molecular level the tumorigenesis barriers normally active in HR-compromised cells and how these are overturned in cancer. You will have a PhD/DPhil in Biology, Biochemistry or related subject and a solid background in molecular biology and a high level of technical competence in cell culture techniques. You will also have a background in senescence and/or DNA damage signalling/repair and a good publication record. Experience in lentiviral/retroviral infection of mammalian cells and high-throughput screens is desirable. This is a full-time post and is available for 3 years in the first instance. All applicants must complete an application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Thursday 17 April 2014.

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Postdoctoral Researcher in Molecular Imaging and Theranostics of Cancer

Closing Date: May 07, 2014 12:00 PM

We have an exciting opportunity for a Postdoctoral Researcher within the Department of Oncology. You will join the group of Professor K Vallis, focusing on translational research in the area of radionuclide imaging and experimental radiotherapeutics. You will lead a research project to design, synthesise and conduct preclinical development of in vivo SPECT and/or PET imaging or theranostic agents, based on modified proteins, antibodies, nucleic acids or nanotechnology approaches. Current themes within the group include targeting of intranuclear molecules for therapy and imaging, innovative nano-medicine drug/radionuclide delivery systems and molecular imaging of angiogenesis and DNA damage. You will have a PhD in Imaging Science, Chemistry, Biochemistry, Pharmaceutical Sciences, Molecular Biology or a related subject. You will also have excellent bench skills in relevant laboratory techniques, along with a strong publication record at the level of first author publication in a leading refereed journal. This is a full-time post and is available until 31 March 2017 in the first instance. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Wednesday 7 May 2014.

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Postdoctoral Researcher

Closing Date: May 12, 2014 12:00 PM

An exciting opportunity has arisen for a Postdoctoral Researcher within the Department of Oncology. You will join Dr Vincenzo D’Angiolella’s research team, which focuses on the mechanisms of maintenance of genome stability. You will undertake state-of-the-art molecular, cell biological and biochemical techniques in order to explore the role of E3 ubiquitin ligases in cancer development and radiotherapy response. You will be involved in a system based approach to identify the genes that lead to genome instability in mammalian cells, and ultimately cancer. You will have a PhD in a relevant subject, as well as a peer-reviewed first author publication. You will also have relevant experience in biomedical research, preferably in cancer biology and metabolism of nucleic acids, including DNA damage response. This is a full-time post and is available until 31 March 2017. All applicants must complete an application form and upload a CV and supporting statement. The closing date for applications is 12.00 noon on Monday 12 May 2014.

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Postdoctoral Researcher in Cancer Metastasis

Closing Date: Jun 19, 2014 12:00 PM

We have an excellent opportunity for a Postdoctoral researcher to join the CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology. You will join a lab studying the interactions between the host and the cancer cell during the initiation and development of cancer metastases. The main aim of this study is to explore the mechanisms through which the myeloid cells support metastasis. The focus will be on the interactions of the myeloid cells and the cancer cells in regulation of the extracellular matrix and angiogenesis. You will have a DPhil or equivalent in relevant subject, along with knowledge of cancer biology and cancer research. You will have effective communication skills and demonstrable ability to evaluate and interpret scientific data. Prior publications in peer-reviewed scientific journals would also be desirable. This is a full-time post and is available until 31 March 2017 in the first instance. All applicants must complete an application form and upload a supporting statement. The closing date for applications is 12.00 noon on 19 June 2014.

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Clinical Research Training Fellowship (3 posts)

Closing Date: Jun 25, 2014 12:00 PM

We are now inviting applications for the 2014 Clinical Research Training Fellowship DPhil intake for the CRUK & MRC Oxford Institute for Radiation Oncology at the University of Oxford. The Fellowships are available to medically qualified individuals who are undertaking their specialist training in any clinical discipline, and who want to obtain a DPhil with a view to an academic career in any branch of cancer research. Candidates must be clinically qualified and able to be GMC registered. Priority will be given to those in training in Radiation/Clinical Oncology and this will be mandatory for some of the clinically orientated projects. Applicants should demonstrate some previous research experience, which may include peer-reviewed publications, and have a strong commitment to the future pursuit of research. We strongly advise prospective applicants to discuss their research interests with potential supervisors prior to applying. Further information on available projects can be obtained from the link below or by contacting Mrs Claire Garbett, PA to Professor Tim Maughan, the Clinical Director of the CRUK & MRC Oxford Institute for Radiation Oncology; email: claire.garbett@oncology.ox.ac.uk or tel: 01865 617415. There are up to three full-time posts available for 3 years in the first instance. In addition to a salary for 3 years, the Fellowship will fund full tuition and college fees for the duration of training. All applicants must complete a short application form and upload a CV, supporting statement and supplementary information form. The closing date for applications is 12.00 noon on 25 June 2014. Interviews are scheduled for Tuesday 8 July 2014.

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